Polynucleotides at Skin CoLAB: The Next Generation of Skin Repair

If you’ve been curious about our Repair Ritual with Polynucleotides, you’re not alone. Clients often ask what polynucleotides are, how they work, and how they compare to microneedling — one of our all-time favorite treatments. Spoiler alert: they might just be your new go-to for next-level skin repair.

What Are Polynucleotides?

Polynucleotides (PN) are fragments of DNA and RNA that act as powerful cellular repair stimulators. Think of them as the “building blocks” your skin uses to renew, repair, and function at its best.

Here’s what they do:

• Stimulate fibroblasts to increase collagen and elastin

• Improve hydration, elasticity, and skin cell turnover

• Offer anti-inflammatory and antioxidant protection

The result? Healthier, plumper, more resilient skin — with a natural glow that starts at the cellular level.

Why Topical Polynucleotide Products Don’t Work

If you’ve seen “salmon DNA” masks or serums trending in K-beauty, you might assume they deliver similar results. Unfortunately, polynucleotides are large, water-based molecules that can’t effectively penetrate the skin barrier through topical use alone.

That’s where microchanneling at Skin CoLAB comes in. Our method delivers these potent molecules directly into the skin — where true repair and regeneration occur. We also use one of the highest-quality salmon DNA formulations available, with a 3% concentration of pure, high-grade polynucleotides — among the best in the industry.

Polynucleotides vs. Microneedling

We love microneedling in Grand Rapids (and always will), but Polynucleotide facials offer a unique edge for certain clients and skin concerns.

Here’s how they compare:

• For acne-prone skin: Traditional microneedling can’t be done over active acne. Our Polynucleotide Facial can. With our Pure Skin Cocktail — featuring white nettle flower and burdock root — we can calm inflammation and support repair simultaneously.

• For busy schedules: Minimal downtime. No redness, no peeling — just smoother, calmer skin.

• For aging prevention: Polynucleotides don’t just trigger healing; they future-proof the skin, helping it respond more youthfully to stress and environmental changes.

This makes them ideal for clients in their 30s–40s noticing slower skin recovery and early loss of elasticity.

A Game-Changer for Perimenopausal Skin

Hormonal shifts during perimenopause can lead to dryness, thinning, and slower skin turnover. Polynucleotides help restore hydration, elasticity, and firmness — especially when paired with MYSTRŌ Revive Serum and our other regenerative treatments.

If you’re experiencing changes in your skin and want to maintain youthful resilience, this gentle yet powerful option supports your skin’s natural ability to heal and thrive.

Treatment Recommendations

For general rejuvenation or light texture concerns:

• 3–4 treatments, spaced four weeks apart

• Quarterly maintenance sessions for lasting results

For clients addressing deeper acne scarring, we often recommend a microneedling series followed by Polynucleotide treatments for long-term support and skin strengthening.

Why We Love It

Polynucleotides get a big yes from our Skin CoLAB providers. This science-driven ritual bridges the gap between repair and prevention, offering visible results without significant downtime.

Whether your goal is to:

• Calm and heal acne-prone skin

• Minimize fine lines and texture

• Support your perimenopausal skin

• Or simply boost long-term skin health

…the Polynucleotide Repair Ritual delivers a clinical yet elegant experience that’s uniquely Skin CoLAB.

Ready to try the Polynucleotide Facial at Skin CoLAB? Experience advanced, medically led skin rejuvenation in Grand Rapids — designed for real results and real life.👉 Book your Repair Ritual here. Special thanks to Alica Hope, Licensed aesthetician at Skin CoLAB for her deep dive into all things polynucleotides!