Salmon Sperm in Skincare?

Salmon Sperm in Skincare? Let’s Talk PDRN + PN 🧬

If you’ve been scrolling through social media lately, you may have seen the buzz around PDRN and PN, or even heard someone mention salmon sperm skincare (yes, you heard that right 😅). So why on earth would anyone put that on their skin? Let’s break it down.

First off—no, it’s not actual salmon sperm. What’s being used is purified DNA derived from salmon sperm, which is separated into two powerhouse forms: PDRN and PN.

🧬 The Science: PDRN vs. PN

Both PDRN and PN come from salmon DNA, but they differ slightly in size and concentration.

• PN (Polynucleotide) is the umbrella term for long chains of DNA fragments that help repair damaged skin, improve elasticity, and boost cellular regeneration.

• PDRN (Polydeoxyribonucleotide) is a specific type of PN; smaller, standardized, and clinically refined for use in skincare and medical aesthetics.

  
  

In short:👉 All PDRN is PN, but not all PN is PDRN.

• PDRN is typically found in topical skincare for gentle repair and hydration.

• PN is used in advanced aesthetic treatments for deeper, more transformative rejuvenation.

Here’s how that translates for your skin:

Scientists extract and purify the DNA from salmon sperm to create polynucleotides — molecules that naturally encourage your skin to repair itself, boost collagen and elastin, and restore a healthy glow.

Depending on the formulation, you may see the ingredient listed as PDRN or PN. Both are powerful, but PN penetrates deeper and triggers more robust regeneration, making it ideal for in-office facial treatments.

✨ PN in Action at Skin CoLAB

At Skin CoLAB, a leading med spa in Grand Rapids, we use PN in our exclusive Polynucleotide Repair Ritual: a luxury facial treatment that delivers this next-generation ingredient exactly where your skin needs it most.

The experience begins with deep cleansing, gentle exfoliation through precise dermaplaning, and a heavenly lymphatic facial massage. We then activate your skin’s repair process with targeted red-light therapy before applying a customized PN Lumicen solution via nanoneedling.

This combination stimulates collagen remodeling, refines texture, and restores radiance from the inside out. After your treatment, you may notice mild pinkness for a day as your skin begins its renewal phase — so we recommend skipping makeup and skincare until the next morning.

Clients have described their post-treatment glow as “glass skin,” “baby-soft,” and “radiant.”

So, Which Is Better — PDRN or PN?

The truth? Both have their place in modern aesthetics.

At Skin CoLAB, every treatment is guided by one core principle: measurable, clinical results. That’s why we’ve partnered with Toskani MED to bring you our signature Repair Ritual Facial, a treatment built on science, precision, and proven skin restoration.

✨ Visit our Grand Rapids med spa or explore our website to learn more about the

: where luxury meets modern skin science.

Thank you to Kendall, LE for her contribution to this article.